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Arimidex is contraindicated in any type of patient which has revealed an irritation reaction to the drug or to any one of the excipients. Noted reactions include anaphylaxis, urticaria, and angioedema [see Adverse Reactions (6.

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In ladies with pre-existing heart disease, a raised incidence of ischemic cardio events was observed with Arimidex in the ATAC trial (17 % of individuals on Arimidex and 10 % of individuals on tamoxifen). Consider threat and advantages of Arimidex treatment in people with pre-existing heart disease [see Adverse Reactions (6.

Arise from the ATAC trial bone substudy at 12 and 24 months showed that people getting Arimidex had a mean decline in both back spinal column and overall hip bone tissue mineral density (BMD) as compared to standard. Individuals obtaining tamoxifen had a mean increase in both lumbar spinal column and also complete hip BMD as compared to standard. Take into consideration bone mineral thickness monitoring in people treated with Arimidex [see Adverse Reactions (6.

Throughout the ATAC test, even more clients receiving Arimidex were stated to have elevated lotion cholesterol levels compared with individuals getting tamoxifen (9 % versus 3.5 %, specifically) [see Adverse Reactions (6.

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Severe damaging responses with Arimidex occurring in much less compared to 1 in 10, 000 individuals, are: 1) skin responses such as sores, lesions, or ulcers; 2) sensitive reactions with swelling of the face, lips, tongue, and/or throat. This could trigger trouble in swallowing and/or breathing; and also 3) modifications in blood examinations of the liver feature, including inflammation of the liver with symptoms that may include a general feeling of not being well, with or without jaundice, liver pain or liver swelling [see Adverse Reactions (6.